The Long Version

Retired broadcast journalist. Blogging helps scratch the itch. Recovering exRepublican – Sober and still Conservative.

Posts Tagged ‘Covid Pill

Pfizer Creates New Version of Ivermectin to Save the World

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The “I” word. That word that makes Fauci, Democrats, and pharmaceutical executives fume and raise their fists in defiant opposition. It made them so angry they created a campaign to discredit it and ban it. It made them so mad they asked their pals in the legacy media to call it horse and cow dewormer and mock anyone who said it should be considered as an effective early treatment for Covid-19.

Ivermectin. A medication used to treat parasite infestations. In humans, these include head lice, scabies, river blindness, strongyloidiasis, trichuriasis, ascariasis, and lymphatic filariasis. In veterinary medicine, the medication is used to prevent and treat heartworm and acariasis, among other indications.

Yet thousands of physicians, nurses, medical researchers, and other health care professionals discovered it provided amazing benefits to covid patients at all stage of the illness. These people were quickly shut down, threatened, mocked, and attacked by the legacy news media and the trolls of social media.

Dr. John Campbell PhD, trains nurses and develops open learning resources for nurses and health care professionals. He broke down the hard core science behind the Pfizer pill and Ivermectin and provided a clear and easy to understand comparison which shows Ivermectin to be KING and the new Pfizer pill to be a functional copy of Ivermectin. In other words the two “act” and work in the body in the same way. Ivermectin just does a better job of it.

That won’t stop Joe Biden and Anthony Fauci and the CDC and their water boys at the legacy media from continuing to carry their disinformation and misinformation about Ivermectin to the eyes and ears of the public so they can convince them their NEW PILL is the answer to the pandemic. Of course their new pill will cost 10 times or more what Ivermectin does.

Here’s the goods:

New Pfizer antiviral and ivermectin, a pharmacodynamic analysis by Dr. John Campbell.

New Pfizer antiviral, PF-07321332, C₂₃H₃₂F₃N₅O₄ PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,

https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate

So, what is a protease? So what is a protease inhibitor? And, what is 3CL? Chymotrypsin-like protease (3CL main protease, or 3CL Mpro)

Identification of SARS-CoV‑2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening (3rd September 2020)

https://pubs.acs.org/doi/abs/10.1021/acsptsci.0c00108#

The activity of the anti-SARS-CoV-2 viral infection was confirmed in 7 of 23 compounds. Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection.

https://pubs.rsc.org/en/content/articlehtml/2021/cp/d1cp02967c

The strength and persistency of the interaction between IVE and the binding site of 3CLpro indicate that a partial inhibition of the catalytic activity could have place as the drug interacts with the main subdomains that define the enzyme binding pocket: Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents.

https://www.nature.com/articles/s42003-020-01577-x

As shown in Fig. 4, out of 13 OTDs only ivermectin completely blocked ( more than 80%) the 3CLpro activity at 50 µM concentration.

Development, validation, and approval of COVID-19 specific drugs takes years. Therefore, the idea of drug repositioning, also known as repurposing, is an important strategy to control the sudden outbreak of life-threatening infectious agents that spread rapidly.

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study.

https://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra06379g

From the docking analysis, ivermectin showed the highest docking score with an average energy of −8.5 kcal mol−1 among all the compounds. Remdesivir showed the lowest binding energy and highest docking score of −9.9 kcal mol−1

Ivermectin, C48H74O14 – Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach…

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/

We have documented an intense binding of both ivermectin B1a and B1b isomer to the main protease with subsequent energy (ETot-) values of -384.56 and -408.6.

PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease.

https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate

Risk of virus developing resistance to PF-07321332

Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2

https://www.frontiersin.org/articles/10.3389/fmicb.2020.592908/full

With SARS-CoV-2 S Spike protein Ivermectin showed high binding affinity to the viral S protein as well as the human cell surface receptors ACE-2 and TMPRSS2.

In agreement to our findings, ivermectin was found to be docked between the viral spike and the ACE2 receptor. Binding Interactions of Selected Drugs With Human TMPRSS2 Protein (ACE2 protein). The docking results revealed that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −174.971) and protein–ligand interactions.

Binding Interactions of Selected Drugs With Human ACE-2 Protein, ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −159.754) and protein–ligand interactions.

With SARS-CoV-2 S Glycoprotein Ivermectin showed the highest binding affinity to the predicted active site of the protein.

With SARS-CoV-2 Nsp14 Protein ivermectin showed the highest binding affinity (MolDock score −212.265) and protein–ligand interactions.

Binding Interactions of Selected Drugs With SARS-CoV-2 PLpro Ivermectin showed the highest binding affinity to the predicted active site of the protein (MolDock score −180.765) and protein–ligand interactions. – END

Bottom line: Ivermectin WORKS. Pfizer knows it. Moderna knows it. Merc knows it. Joe Biden, Tony Fauci, and the Democrats know it. They’ve known it since the beginning. They intentionally lied about it and spread disinformation using their pets in the legacy media. They pilloried anyone who tried to tell the truth. They got the top dogs at the AMA and all the medical societies to go along and put the hammer down on any physicians, nurses, or other medical professionals who even questioned their mandates.

It boggles the mind how effective the propaganda and coercion has been and how many Americans STILL believe the fools running the show.

Written by DCL

November 17, 2021 at 9:59 am